By Other binding to the adaptor protein SKP1 and serving as substrate receptors for the SKP1 Cullin, F-box E3 ubiquitin ligase complex, F-box proteins regulate critical cellular processes including cell cycle progression and membrane trafficking.While F-box proteins are conserved throughout eukaryotes and are well studied in yeast, plants, and anim

The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of nociceptive messages.Plastic changes in the properties of neuronal networks in the DH underlie the development of analgesia as well as of hyperalgesia and allodynia in acute and chronic pain states.Two key mechanisms are involved in these chronic pain s